Tesamorelin (Egrifta): GHRH Analogue for HIV Lipodystrophy
Synthetic GHRH analogue. FDA-approved for HIV-associated visceral-fat excess; reduces abdominal fat by ~18%.
Growth Hormone & IGF-1 Peptides
Secretagogues (GHRH analogs, GHRP family, ghrelin mimetics) and IGF-1 variants. Span FDA-approved agents (tesamorelin via our compare pages), research peptides (ipamorelin, CJC-1295, hexarelin), oral mimetics (MK-677), and engineered analogs (IGF-1 LR3, PEG-MGF). Most are not approved for general human use.
Peptides in this category
Ipamorelin
A selective growth hormone secretagogue with real human pharmacology data — and a Phase 3 programme for postoperative ileus that did not meet its endpoints
CJC-1295
A long-acting GHRH analogue with real Phase 1 human pharmacology data — and two distinct versions that are routinely sold under the same name
GHRP-6: Growth Hormone-Releasing Peptide-6
First-generation synthetic hexapeptide ghrelin mimetic. Induces strong hunger alongside GH release. Not an approved medicine.
GHRP-2 (Pralmorelin): Growth Hormone-Releasing Peptide-2
Synthetic hexapeptide ghrelin mimetic. Used in some countries as a diagnostic for GH deficiency; not approved for therapeutic use in most.
Hexarelin: Hexapeptide GH Secretagogue with Cardiac Activity
Synthetic six-amino-acid ghrelin mimetic. Potent GH release and direct cardiac-receptor activity; investigational, never approved.
MK-677 (Ibutamoren): Oral Ghrelin Mimetic / GH Secretagogue
Oral, once-daily non-peptide ghrelin receptor agonist. Raises GH and IGF-1 but failed Phase 3 for sarcopenia; not an approved medicine.
PEG-MGF: PEGylated Mechano Growth Factor (IGF-1Ec)
PEGylated splice variant of IGF-1 (IGF-1Ec) released by mechanically loaded muscle. Pre-clinical regenerative evidence; no approved human use.
IGF-1 LR3: Long-Acting Analogue of Insulin-Like Growth Factor-1
Recombinant IGF-1 with an extended N-terminus and Arg-for-Glu substitution. Long-acting, low IGFBP affinity. Used in cell culture; not approved for humans.
Follistatin-344: Myostatin and Activin-Binding Protein
Splice variant of the follistatin gene that binds and neutralises myostatin and activins. Pre-clinical muscle growth effects; no human approval.
hGH Fragment 176-191: Native C-Terminal Fragment of Growth Hormone
Unmodified C-terminal fragment of human growth hormone. Rodent lipolysis data; no approved human use. Closely related to AOD-9604.